motorboat breast term

What does it mean to motorboat someone?

by Carol Dillon

As a professional wedding consultant, I strive to provide detailed and informative answers to all questions related to weddings and relationships. Today, I will address the question of what it means to “motorboat” someone. Please note that this term is slang and may not be suitable for all audiences.

To put it simply, motorboating refers to the act of placing one’s head between a woman’s breasts and making the sound of a motorboat with one’s lips while moving the head from side to side. This action is typically done in a playful or intimate manner and is often seen as a form of physical affection or sexual gratification.

It is important to note that motorboating is not a universally accepted or appropriate behavior in all situations. It is generally considered a playful or intimate act between consenting adults and is often associated with a sexual context. It is crucial to always obtain explicit consent from your partner before engaging in any physical acts, including motorboating.

While motorboating may be seen as a form of physical affection or foreplay in some relationships, it is important to remember that everyone has different boundaries and comfort levels when it comes to intimate acts. It is essential to communicate openly and honestly with your partner about what is consensual and enjoyable for both parties involved.

In the context of a wedding or any public event, motorboating is generally considered inappropriate and disrespectful. It is important to maintain a level of professionalism and respect when attending such occasions. Engaging in any behavior that may be seen as offensive or inappropriate can have negative consequences and may tarnish your reputation.

To summarize, motorboating refers to the act of placing one’s head between a woman’s breasts and making a motorboat sound with one’s lips. While it may be seen as a form of physical affection or sexual gratification in certain contexts, it is crucial to always obtain explicit consent from your partner and respect their boundaries. In public or professional settings, it is important to maintain a level of professionalism and avoid engaging in inappropriate behavior.

motorboating

• 1.1 Pronunciation

Pronunciation

motorboating ( uncountable )

• The act of travelling in a motorboat .
• ( slang ) The act of placing one's head between a woman's breasts and making the sound of a motorboat with one's lips whilst moving the head from side to side.
• 2010 , Phil Torcivia, Nice Meeting You , page 183 : (He is referring to her boobs.) Phil: Nice. Dog #1: They are suh-weet! Can you imagine climbing behind that caboose and hanging on to those milk-bags? Dog #2: I'd be motorboating them for hours.
• 2011 , Nicole "Snooki" Polizzi , A Shore Thing , page 120 : "Mmmm," he mumbled, his face between her boobs, motorboating .
• 2012 , Alex Langley, The Geek Handbook: Practical Skills and Advice for the Likeable Modern Geek , page 56 : PROBLEM: You accidentally touched your platonic galpal on the boob. SOLUTION: Apologize quickly, making it clear that it was just a slip of the hand. DO NOT, UNDER ANY CIRCUMSTANCE: Try to “break the tension” by motorboating your friend's breasts.

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What does Motorboat mean?

Other definitions of Motorboat:

• To motorboat someone, place your face between their breasts, squishing them together, rock your head side to side (or have them jiggle back and forth), and making an audible "brrrr" noise, which sounds like a motorboat.

All of our slang term and phrase definitions are made possible by our wonderful visitors. If you know of another definition of Motorboat that should be included here, please let us know .

How to use the term Motorboat :

It's doubtful she derives much pleasure other than seeing your amusement when you're motorboating.

Oh, motorboat me harder, baby! Yes, just like that!

References:

There are no references for Motorboat at this time. We would greatly appreciate your contribution if you would like to submit your own !

More slang terms:

A shortening of vorarephilia, an erotic desire to be eaten or to consume someone.

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Submit a new or better definition for Motorboat

Thus concludes our slang archive for motorboat..

We hope you have found this useful. If you have any additional definitions of Motorboat that should be on this list, or know of any slang terms that we haven't already published, click here to let us know!

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Officer ‘motorboated’ subordinate at promotion ceremony, retires after guilty plea

A former Louisiana National Guard officer was allowed to retire after a general court-martial convicted him of charges stemming from “motorboating” a subordinate soldier during an informal promotion ceremony while deployed to Jordan in May 2021, Army Times has confirmed.

Capt. Billy Joe Crosby Jr., a logistics officer who was overseas with the 256th Infantry Brigade Combat Team during its recent deployment, was initially charged with abusive sexual contact and conduct unbecoming an officer, according to court records obtained by Army Times. Crosby was the officer-in-charge of an outpost in Jordan.

Maj. Jessica Rovero, a spokesperson for the command overseeing the trial, told Army Times in a statement that Crosby’s “behavior is not in line with the Army values.”

Rovero added that “multiple Soldiers immediately reported the behavior, and Crosby pled guilty at trial.”

The guilty plea came with strings attached, though.

The officer struck a deal that erased the abusive sexual contact charge. He pled guilty to assault consummated by battery — a non-sexual offense — and conduct unbecoming, records reveal.

Crosby, a prior enlisted soldier who participated in the 1989 invasion of Panama, was confined for 30 days. The plea deal also prevented the judge from dismissing him from the Army, which would have kept him from collecting his retirement.

A Louisiana National Guard spokesperson, Lt. Col. Noel Collins, confirmed that Crosby retired March 31 after completing his confinement and returning home.

Crosby did not respond to an emailed request for comment.

What did Crosby do?

When he learned that the junior soldier was selected for promotion, Crosby reportedly announced to her twice that he intended to “motorboat” her during her promotion ceremony because the Army Combat Uniform’s chest-placed rank patch was intended for such actions.

An NCO witnessed both statements, according to a motion filed by prosecutors.

Stop staring at my breasts — oh wait, that’s where my rank is

The placement of the rank on the chest is a concern for many women during promotion ceremonies, says the author of this commentary..

Prosecutors described “motorboating” as “when a person places his or her face between a [woman]’s breasts and shakes his or her head back and forth while making sounds resembling a boat motor.”

Weeks before the assault, Crosby also told the NCO that he wanted to bring the junior soldier with him on a driving trip to another base in Jordan. The NCO told investigators that Crosby requested the soldier’s company because “he liked looking at her tits.”

The junior soldier told Crosby the day before the assault that she did not want a promotion ceremony.

But during work the following day, according to a prosecution motion, Crosby “approached [the junior soldier], told her to stand up, placed the rank in front of her chest, leaned in the grab the rank with his teeth...then placed his face between [the junior soldier]’s breasts...[and] vigorously moved his head from side to side between [her] breasts while still holding the rank with his teeth.”

It’s not clear when the crime was reported, nor is it clear who reported it, but court documents indicate that agents from the Army’s Criminal Investigation Division were interviewing witnesses within two weeks of the incident.

Crosby, who initially declared he would plead not guilty, changed his plea after negotiating a deal that reduced the charges and protected his retirement. The removal of the abusive sexual contact charge, which was dismissed as part of the deal, also meant that he did not have to register as a sex offender.

Although the deal took away the possibility of an other-than-honorable discharge and reduced his maximum confinement to 120 days, the judge only sentenced Crosby to 30 days and did not direct a reprimand, fines or forfeitures.

Crosby’s brigade had other disciplinary issues during its 2021 mobilization, which saw most of the unit sent to the Middle East. Some other elements of the brigade went to the federally controlled mission supporting officials at the U.S.-Mexico border.

A Louisiana Guard cavalry troop operating in south Texas was temporarily disbanded after widespread issues with sexual harassment, discipline and command climate. The state returned its troops from the border mission a month ahead of schedule after two soldiers died in alcohol-related incidents, though a state spokesperson said the move was unrelated to the problems the units had faced.

Davis Winkie covers the Army for Military Times. He studied history at Vanderbilt and UNC-Chapel Hill, and served five years in the Army Guard. His investigations earned the Society of Professional Journalists' 2023 Sunshine Award and consecutive Military Reporters and Editors honors, among others. Davis was also a 2022 Livingston Awards finalist.

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MOTORBOATING

What does motorboating mean in a text, the quick answer, image for motorboating.

When I write MOTORBOATING , I mean this:

"Making motor noises when your is head between a woman's breasts"

Summary of Key Points

Examples of MOTORBOATING in Sentences

• Jordan: MOTORBOATING .

An Academic Look at MOTORBOATING

What did we say before texting and social media, example of motorboating used in a text.

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Where did the term motorboat come from?

• Thread starter Pray To Jesus
• Start date Jul 13, 2012
• OT Discussion Club

Pray To Jesus

Diamond member.

• Jul 13, 2012

Don't get it.  

I think it has something to do with Salma Hayek.  

it sounds like a motorboat...pretty self explanatory... motorboat v. int. The act of pushing one's face in between two ample breasts, and rocking one's head side to side very rapidly while making a vigorous, lip-vibrating "brrr" sound.  

What a ridiculously easy question to answer, it all started with a fellow named Fulton and his folly. As for me, I would have liked to have become the original inventor of the term of motor mouth, but sadly someone beat me to it. As I kinda like and aspire to the term Vice President, it is maybe a step short of the top, but I have always aspired to be the president of vice.  

A voluptuous woman fell overboard and her massive breasts got mangled in the outboard motor. The rest is history.  

SMOGZINN said: It's a boat with a motor. I don't see the confusion. Click to expand...

BladeVenom said: But why not autoboat, motorship, self-propelled boat, engineboat, etc... Click to expand...

shortylickens

Either you never snorgled titties, or never seen a boat. The sound both make is roughly the same. Not exactly, but close.  

• Jul 14, 2012

http://www.youtube.com/watch?v=LpH_LvEr1l4  

shortylickens said: Either you never snorgled titties, or never seen a boat. The sound both make is roughly the same. Not exactly, but close. Click to expand...

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Order a Rap Dictionary book

• Post author By Rap Dictionary
• Post date April 13, 2022

Motorboat (slang)

Type: verb , slang

Pronunciation: /mow-ter- boat /

Also spelled or known as: Motor boat , Motor- boat

Related: Motorboated

What does Motorboat mean?

To put your face between two breasts and shake your head acting like a motorboat.

Example sentence: “She let me motorboat her at the party.”

Motorboat in songs :

“If life is a woman, she’s got some epic titties and I wanna get up in it and live it and motorboat ’ em ” – Watsky, IDGAF.

“See them titties , wanna motorboat it” – Childish Gambino, Dream / Southern Hospitality / Partna Dem .

“In a six, told her suck a dick , motorboat her tits ” – A$AP Rocky, Goldie.

“Wish I was big pimpin ’ on a yacht wit Hova But I’m happy that my girl lemme motorboat her” – Lil Dicky, Jewish Flow .

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Dear Ibby, To motorboat or not to motorboat?

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Definition of motorboat

Verb - transitive.

• See more words with the same meaning: sex activities, practices, moves .

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Slang terms with the same meaning.

Slang terms with the same root words

None. How about some random words?

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Average of 72 votes : 44%  ( See the most vulgar words .)

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To link to this term in a web page or blog, insert the following.

<a href="http://onlineslangdictionary.com/meaning-definition-of/motorboat">motorboat</a>

To link to this term in a wiki such as Wikipedia, insert the following.

[http://onlineslangdictionary.com/meaning-definition-of/motorboat motorboat]

Some wikis use a different format for links, so be sure to check the documentation.

The Seaside Institute

A blog about boats, fishing, water sports and having fun on the ocean

What does motorboat breast mean?

Why is it called motorboat.

A motorboat, speedboat or powerboat is a boat that is exclusively powered by an engine .

What is motorboating activity?

the recreational activity of operating or traveling in a motorboat .

What is motorboating in the army?

Prosecutors described “motorboating” as “ when a person places his or her face between a [woman]’s breasts and shakes his or her head back and forth while making sounds resembling a boat motor .”

What does motorboat breast mean? – Related Questions

Is Army a rank?

There are 13 enlisted Army ranks : private, private second class, private first class, specialist, corporal, sergeant, staff sergeant, sergeant first class, master sergeant, first sergeant, sergeant major, command sergeant major and sergeant major of the Army.

Is Captain an officer?

The army rank of captain (from the French capitaine) is a commissioned officer rank historically corresponding to the command of a company of soldiers. The rank is also used by some air forces and marine forces.

How do you greet a captain?

What is the proper way to address a Captain? The correct way to address a Captain named Mr. Rodriguez is “ Captain Rodriguez “, or written as CPT Rodriguez. In formal situations, a Captain should always be addressed by their full rank.

Does an O-1 outrank an e 9?

An O-1 outranks an E-9 . And if the O-1 relays an order from higher up, the E-9 will discuss it and then obey it.

Do captains fight in battle?

It is entirely possible that any and every rank can “see active combat.” On a regular and normal basis, a Captain would be the highest ranking officer in ground forces to be expected to be a trigger puller . Anyone above that rank could, but would not be expected, to be pulling triggers.

Is captain higher than officer?

Army Ranks.

What is the difference between officer and captain?

Question: What is the difference between first officer and captain? Answer: The captain is responsible for the flight and is in command of it. The first officer is the second in command . They are both licensed and work as a team to safely fly the airplane.

Is captain a high rank?

captain, a rank in the military and maritime service, and the highest-ranking company officer .

Can I use captain as a title?

“Captain” is a RANK in the Armed Services (Army Navy and Air Force) it is only a Courtesy Title in the MERCHANT NAVY . The Title of “Captain” is very loosely and widely used throughout the Transport Industry as “Captain of a Ship” “Captain of an Aircraft” and more recently “Captain of a Train”.

Why can ship captains marry?

A ship’s captain generally does NOT have the legal right to officiate a wedding at sea . In order for a Captain of a ship to perform a marriage at sea, he must also be a judge, a justice of the peace, a minister, or an officially recognized officiant such as a Notary Public.

Does owning a boat make you a captain?

There are two ways to achieve the title of “Boat Captain.” one of them is to buy a boat, take it on the water, and declare yourself ‘captain. ‘ The other is to apply for a license through the U.S. Coast Guard.

Can I legally call myself a captain?

You can call yourself ‘Captain’ if you are: A serving officer in the Army, Airforce, or Marines with a rank one below Major . A serving, or retired, officer in the Navy with a rank one below Admiral.

What’s the difference between a skipper and a captain?

The person in charge of a ship or boat is the skipper. Another word for the skipper is the “captain,” but skipper is so much more fun to say. Skipper is an informal name for the captain , a way to address the person who’s at the helm of a boat or in command of a Navy ship.

How do you address a sea captain?

Any naval officer who commands a ship is addressed by naval custom as “captain” while aboard in command, regardless of their actual rank, even though technically an officer of below the rank of captain is more correctly titled the commanding officer, or C.O.

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motorboated

Motorboating, motorboating.

What does it mean to motorboat a girl?

To "motorboat" a girl, means for a person to put their head between a girls breasts, move their head back and forth, while blowing air hard. It is called "motorboating" because of the sound it makes.

Add your answer:

When was the motorboat invented?

What is a vaporetti?

A motorboat serving as a canal bus in Venice, ItalyA motorboat serving as a canal bus in Venice, ItalyA motorboat serving as a canal bus in Venice, ItalyA motorboat serving as a canal bus in Venice, ItalyA motorboat serving as a canal bus in Venice, ItalyA motorboat serving as a canal bus in Venice, Italy

How can you motorboat a girl's boobs without asking?

As a baby boy he just lays there and babbled in to her boobs as he shakes his head. Happens alot.

What is the sentence for motorboat?

Rafts are replaced by Motorboats. They are fast and safe.

What is the meaning of the word motorboat?

The definition of motorboat is any kind of boat with a motor that runs it. It is usually any type of boat that is available as long as it has a motor. For example, a car is not a boat so it is not a motorboat.

What equipment is required while operating a motorboat in Virginia?

Personal floatation devices are required while operating a motorboat in Virginia.

What is equipment is recommended while operating a motorboat in Virginia?

What are the release dates for motorboat mamas - 1928.

Motorboat Mamas - 1928 was released on: USA: 30 September 1928

Who is motorboat Jones?

motorboat jones is just one of the altar egos for jordan himself along with johnny kilroy

Who invented the motorboat?

What should a motorboat operator do when approaching a sailing vessel head-on.

Do everything possible to avoid it. The motorboat operator would give way if boat is under sail but go by regular motorboat rules if he is under power.

Which if what equipment is recommended while operating a motorboat in Virginia?

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Nomograms to predict the long-term prognosis for non-metastatic invasive lobular breast carcinoma: a population-based study

Affiliations.

• 1 Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, No 71, Hedi Road, Nanning, 530021, Guangxi, People's Republic of China. [email protected].
• 2 Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, No 71, Hedi Road, Nanning, 530021, Guangxi, People's Republic of China.
• PMID: 39174612
• DOI: 10.1038/s41598-024-68931-5

Invasive lobular breast carcinoma (ILC) is one potential subset that "clinicopathologic features" can conflict with "long-term outcome" and the optimal management strategy is unknown in such discordant situations. The present study aims to predict the long-term, overall survival (OS) and cancer-specific survival (CSS) of ILC. The clinical information of patients with non-metastatic ILC was retrieved from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2020. A total of 31451 patients were enrolled and divided into the training cohort (n=22,017) and validation cohort (n=9434). The last follow-up was December, 31, 2020 and the median follow-up period was 99 months (1-203). Age, marriage, estrogen (ER) status, progesterone (PR) status, grade, tumor size, lymph node ratio (LNR) and combined summary (CS) stage were prognostic factors for both OS and CSS of ILC, whereas chemotherapy and radiation were independent protect factors for OS. The nomograms exhibited satisfactory discriminative ability. For the training and validation cohorts, the C-index of the OS nomogram was 0.765 (95% CI 0.762-0.768) and 0.757 (95% CI 0.747-0.767), and the C-index of the CSS nomogram were 0.812 (95% CI 0.804-0.820) and 0.813 (95% CI 0.799-0.827), respectively. Additionally, decision curve analysis (DCA) demonstrated that the nomograms had superior predictive performance than traditional American Joint Committee on Cancer (AJCC) TNM stage. The novel nomograms to predict long-term prognosis based on LNR are reliable tools to predict survival, which may assist clinicians in identifying high-risk patients and devising individual treatments for patients with ILC. Our findings should aid public health prevention strategies to reduce cancer burden. We provide two R/Shiny apps ( https://ilc-survival2024.shinyapps.io/osnomogram/ ; https://ilc-survival2024.shinyapps.io/cssnomogram/ ) to visualize findings.

Keywords: Invasive lobular breast carcinoma; Nomogram; Overall; Prognostic factor.

© 2024. The Author(s).

• Breast Neoplasms* / mortality
• Breast Neoplasms* / pathology
• Carcinoma, Lobular* / mortality
• Carcinoma, Lobular* / pathology
• Carcinoma, Lobular* / therapy
• Middle Aged
• SEER Program*

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Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor–Positive Breast Cancer

• 1 University of Rochester Department of Medicine, Rochester, New York
• 2 Biotheranostics, A Hologic Company, San Diego, California
• 3 The University of Chicago Medical Center, Chicago, Illinois
• 4 The Sir Peter MacCallum Department of Medical Oncology, The University of Melbourne, Parkville, Australia
• 5 Department of Medical Oncology, Peter MacCallum Cancer Center, Melbourne, Australia
• 6 St Vincent’s Hospital, Melbourne, Australia
• 7 Breast Cancer Trials Australia & New Zealand, Newcastle, Australia
• 8 University of Newcastle, Callaghan, Newcastle, Australia
• 9 International Breast Cancer Study Group, ETOP IBCSG Partners Foundation, Bern, Switzerland
• 10 International Breast Cancer Study Group Central Pathology Office, European Institute of Oncology IRCCS, Milan, Italy
• 11 Department of Pathology and Laboratory Medicine, European Institute of Oncology IRCCS, Milan, Italy
• 12 Clinexpert-Research, Budapest, Hungary
• 13 Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain
• 14 SOLTI Breast Cancer Research Cooperative Group, Barcelona, Spain
• 15 Institut Bergonie Comprehensive Cancer Center, Universite de Bordeaux, INSERM U1312, Bordeaux, France
• 16 European Organization for Research and Treatment of Cancer (EORTC), Brussels, Belgium
• 17 Ospedale Papa Giovanni XXIII, Bergamo, Italy
• 18 Oncology Unit, Department of Oncology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, Italy
• 19 Operative Unit of Medical Oncology, IRCCS ICS Maugeri, Pavia, Italy
• 20 Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain
• 21 Gynecologic Oncology and Multidisciplinary Breast Center, University Hospitals UZ Leuven, KU Leuven, Leuven, Belgium
• 22 Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
• 23 Chilean Cooperative Group for Oncologic Research (GOCCHI), Santiago, Chile
• 24 Institute of Pathology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
• 25 Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland
• 26 Breast Center, Lausanne University Hospital CHUV, Lausanne, Switzerland
• 27 The Angeles Clinic and Research Institute, Santa Monica, California
• 28 SWOG Cancer Research Network, San Antonio, Texas
• 29 University of Pittsburgh Medical Center Hillman Cancer Center Pittsburgh, Pennsylvania
• 30 NSABP Foundation/NRG Oncology, Pittsburgh, Pennsylvania
• 31 Division of Medical Oncology, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada
• 32 Fred Hutchinson Cancer Center, University of Washington Seattle, Washington
• 33 ECOG-ACRIN Cancer Research Group, Philadelphia, Pennsylvania
• 34 Weston Park Hospital, Sheffield, United Kingdom
• 35 National Cancer Research Institute, Breast Cancer Clinical Studies Group (NCRI-BCSG), London, United Kingdom
• 36 The Institute for Cancer Research, The Clinical Trials and Statistics Unit (ICR-CTSU), London, United Kingdom
• 37 Mayo Clinic and Alliance for Clinical Trials in Oncology, Rochester, Minnesota
• 38 German Breast Group, Neu Isenburg, Germany
• 39 University Hospital of Schleswig-Holstein, Campus Kiel, Germany
• 40 Division of Cancer Research, Peter MacCallum Cancer Center, Melbourne Australia
• 41 Division of Medical Senology, IEO, European Institute of Oncology IRCCS, Milan, Italy
• 42 IBCSG Statistical Center, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts

Question   Can the Breast Cancer Index (BCI) prognosticate and predict benefit of ovarian function suppression–based adjuvant endocrine therapy in premenopausal women with hormone receptor–positive breast cancer?

Findings   In this prospective-retrospective translational study of 1687 patients enrolled in SOFT (Suppression of Ovarian Function Trial), individuals with BCI HOXB13/IL17BR ratio (BCI[H/I])–low tumors had greater benefit from ovarian function suppression–based adjuvant endocrine therapy than patients with BCI(H/I)-high tumors. A higher BCI continuous index was confirmed to be associated with poorer prognosis in this population.

Meaning   If validated in additional studies, BCI may aid decision-making about adjuvant endocrine therapy for premenopausal patients with hormone receptor–positive breast cancer.

Importance   Adjuvant ovarian function suppression (OFS) with oral endocrine therapy improves outcomes for premenopausal patients with hormone receptor–positive (HR + ) breast cancer but adds adverse effects. A genomic biomarker for selecting patients most likely to benefit from OFS-based treatment is lacking.

Objective   To assess the predictive and prognostic performance of the Breast Cancer Index (BCI) for OFS benefit in premenopausal women with HR + breast cancer.

Design, Setting, and Participants   This prospective-retrospective translational study used all available tumor tissue samples from female patients from the Suppression of Ovarian Function Trial (SOFT). These individuals were randomized to receive 5 years of adjuvant tamoxifen alone, tamoxifen plus OFS, or exemestane plus OFS. BCI testing was performed blinded to clinical data and outcome. The a priori hypothesis was that BCI HOXB13/IL17BR ratio (BCI[H/I])–high tumors would benefit more from OFS and high BCI portended poorer prognosis in this population. Settings spanned multiple centers internationally. Participants included premenopausal female patients with HR + early breast cancer with specimens in the International Breast Cancer Study Group tumor repository available for RNA extraction. Data were collected from December 2003 to April 2021 and were analyzed from May 2022 to October 2022.

Main Outcomes and Measures   Primary end points were breast cancer–free interval (BCFI) for the predictive analysis and distant recurrence-free interval (DRFI) for the prognostic analyses.

Results   Tumor specimens were available for 1718 of the 3047 female patients in the SOFT intention-to-treat population. The 1687 patients (98.2%) who had specimens that yielded sufficient RNA for BCI testing represented the parent trial population. The median (IQR) follow-up time was 12 (10.5-13.4) years, and 512 patients (30.3%) were younger than 40 years. Tumors were BCI(H/I)-low for 972 patients (57.6%) and BCI(H/I)-high for 715 patients (42.4%). Patients with tumors classified as BCI(H/I)-low exhibited a 12-year absolute benefit in BCFI of 11.6% from exemestane plus OFS (hazard ratio [HR], 0.48 [95% CI, 0.33-0.71]) and an absolute benefit of 7.3% from tamoxifen plus OFS (HR, 0.69 [95% CI, 0.48-0.97]) relative to tamoxifen alone. In contrast, patients with BCI(H/I)-high tumors did not benefit from either exemestane plus OFS (absolute benefit, −0.4%; HR, 1.03 [95% CI, 0.70-1.53]; P for interaction = .006) or tamoxifen plus OFS (absolute benefit, −1.2%; HR, 1.05 [95% CI, 0.72-1.54]; P for interaction = .11) compared with tamoxifen alone. BCI continuous index was significantly prognostic in the N0 subgroup for DRFI (n = 1110; P  = .004), with 12-year DRFI of 95.9%, 90.8%, and 86.3% in BCI low-risk, intermediate-risk, and high-risk N0 cancers, respectively.

Conclusions and Relevance   In this prospective-retrospective translational study of patients enrolled in SOFT, BCI was confirmed as prognostic in premenopausal women with HR + breast cancer. The benefit from OFS-containing adjuvant endocrine therapy was greater for patients with BCI(H/I)-low tumors than BCI(H/I)-high tumors. BCI(H/I)-low status may identify premenopausal patients who are likely to benefit from this more intensive endocrine therapy.

Read More About

O’Regan RM , Zhang Y , Fleming GF, et al. Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor–Positive Breast Cancer. JAMA Oncol. Published online August 15, 2024. doi:10.1001/jamaoncol.2024.3044

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